Miscarriages, down syndrome, and infertility all linked to this hidden DNA process

 

Neil Hunter, a professor in the Department of Microbiology and Molecular Genetics, has discovered a crucial step in how chromosomes stay connected during the development for egg cells and sperm, helping to prevent fertility problems. Photo shows paired chromosomes with crossovers in a mouse oocyte. Credit: Hunter lab/UC Davis

When a woman becomes pregnant, the outcome of that pregnancy depends on many things -- including a crucial event that happened while she was still growing inside her own mother's womb. It depends on the quality of the egg cells that were already forming inside her fetal ovaries. The DNA-containing chromosomes in those cells must be cut, spliced and sorted perfectly. In males, the same process produces sperm in the testes but occurs only after puberty.

"If that goes wrong, then you end up with the wrong number of chromosomes in the eggs or sperm," said Neil Hunter, a professor in the Department of Microbiology and Molecular Genetics at the University of California, Davis. "This can result in infertility, miscarriage or the birth of children with genetic diseases."

#DNA
#Genetics
#MolecularBiology
#DNASequencing
#Genomics
#DNAResearch
#GeneticEngineering
#DNATesting
#DNAReplication
#Biotechnology

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