Lancet Study Questions HbA1c Accuracy for Diabetes in India
A new study published in The Lancet Regional Health has raised concerns over the widespread reliance on glycated haemoglobin (HbA1c) testing for diagnosing and monitoring type-2 diabetes in India. The findings suggest that HbA1c may not accurately reflect true blood glucose levels in large sections of the population, potentially misrepresenting the country’s actual diabetes burden. Why HbA1c May Be Unreliable in India HbA1c reflects the glycation of haemoglobin over the lifespan of red blood cells and is widely used for diabetes diagnosis and long-term glucose monitoring. However, the study highlights that conditions affecting haemoglobin quantity, structure or lifespan can distort HbA1c values. These include anaemia, haemoglobinopathies and red blood cell enzyme disorders such as glucose-6-phosphate dehydrogenase (G6PD) deficiency, all of which are prevalent in India. Risk of Misdiagnosis and Delayed Treatment According to the study, exclusive reliance on HbA1c can lead to both ...