IGF Discovery Offers Hope for Lymphedema Treatment
A newly identified cellular mechanism could pave the way for effective treatment of lymphedema, a chronic and painful swelling disorder with no current cure. The condition arises when the lymphatic system, responsible for transporting fluid through specialised vessels, is damaged. It may be congenital or caused by injury, but most commonly develops after breast cancer treatment involving lymph node removal. The resulting fluid build-up leads to persistent swelling, discomfort and increased infection risk. Breakthrough in Lymphatic Vessel Growth Researchers at Waipapa Taumata Rau, University of Auckland, have identified a cellular process that stimulates the growth of lymphatic vessels. The discovery was led by Dr Jonathan Astin, senior lecturer in molecular medicine and pathology. The team first observed the mechanism in zebrafish, a widely used model organism in biomedical research. They found that insulin-like growth factor (IGF), a molecule long studied for its role in growth...