Cell biologist discovers two proteins are key to proper transfer of genetic material

 



A significant discovery by UC Santa Cruz cell biologist Needhi Bhalla has uncovered the pivotal roles of two proteins—PCH-2 and HIM-3—in ensuring the accurate transfer of genetic material during the formation of eggs and sperm. This process, known as meiotic crossover recombination, is essential for shuffling genetic material between chromosomes, thereby maintaining genetic diversity and preventing disorders such as miscarriages, infertility, birth defects, and cancer. +++++++++++`-````````````````````

In their study, Bhalla's team utilized the roundworm Caenorhabditis elegans to investigate the functions of PCH-2 and HIM-3. They discovered that PCH-2 regulates the number and distribution of crossover events by initially limiting potential crossover sites and later ensuring that at least some crossovers occur, a process known as crossover assurance. HIM-3, on the other hand, assists in organizing chromosomes during meiosis. Together, these proteins fine-tune the crossover process, ensuring both efficiency and accuracy.



This research not only enhances our understanding of genetic inheritance but also holds promise for developing molecular diagnostics to assess risks related to infertility and recurrent miscarriages, potentially guiding reproductive interventions.

#CellBiology
#MolecularBiology
#Genetics
#CellResearch
#Microscopy
#StemCells
#CellDivision
#Meiosis
#ProteinBiology
#LifeSciences


World Cell Biologist Awards: 

Website Link : cellbiologist.org 

Follow Us On : 
Tumblr ; tumblr.ccom/

Comments

Post a Comment

Popular posts from this blog

What is Zolgensma?

Image
  Spinal Muscular Atrophy (SMA) is a rare genetic disease affecting muscle function. In India, treatment options are limited, mainly due to high costs. The gene therapy drug, Zolgensma , costs around 16 crore rupees. Despite this, some families are finding ways to access treatment. About Spinal Muscular Atrophy (SMA) SMA is a genetic disorder that leads to the loss of motor neurons in the spinal cord. This results in muscle weakness and atrophy. Symptoms often appear in infancy. Children may struggle with basic movements like lifting their heads or crawling. Early diagnosis is crucial for effective treatment. About Zolgensma Zolgensma (onasemnogene abeparvovec-xioi) is a revolutionary gene therapy for SMA. It addresses the root cause by replacing the missing or defective SMN1 gene . This therapy can improve motor function in affected children. Although it is costly, it represents hope for many families. SMA is not as rare as once thought. The global prevalence is estimated at 1 in ...
Read more

Uttrakhand Forest Department Establishes Mahabharata Vatika

Image
  The Uttarakhand Forest Department has established two gardens in Haldwani, showcasing plant species referenced in ancient Indian epics. These gardens, named Ramayana Vatika and Mahabharata Vatika, aim to highlight the ecological wisdom embedded in these texts. Mahabharata Vatika Overview Mahabharata Vatika spans one acre and features 37 plant species mentioned in the epic. Chief Conservator of Forests Sanjeev Chaturvedi emphasised the research behind selecting these species. The garden features important plant species such as: Ecological Significance The garden puts stress on the importance of forests as depicted in the Mahabharata. It references the Vana Parva, which discusses tree planting and wildlife conservation . The epic highlights the mutual dependence of tigers and forests, a concept vital to contemporary conservation efforts. Cultural Connections Chaturvedi brought into light that the Mahabharata teaches the spiritual significance of planting trees. He mentioned Bhish...
Read more

CAR T-Cell Therapy for Cancer

Image
  India has recently made strides in cancer treatment with the introduction of CAR T-cell therapy . The results from the first clinical trials have been published in The Lancet, showcasing a remarkable success rate. This therapy is a game changer for patients with blood cancers. It offers hope to those who have exhausted other treatment options. What is CAR T-Cell Therapy? CAR T-cell therapy, or chimeric antigen receptor T-cell therapy, is an innovative treatment that harnesses the body’s immune system. It trains T-cells to target and destroy cancer cells. This therapy is specifically designed for certain blood cancers. It is particularly beneficial for patients whose cancer has relapsed or failed to respond to standard treatments. Clinical Trial The clinical trials reported a response rate of nearly 73%. This indicates that number of patients benefited from the treatment. The trials also provided critical data on survival rates for patients with acute lymphoblastic leukaemia and l...
Read more