Subabul Seedpods Show Promise for Diabetes Management

 



Recent research marks the potential of Subabul seedpods in managing insulin resistance associated with type II diabetes. This traditional medicinal plant, known scientifically as Leucaena leucocephala, is prevalent in tropical and subtropical regions.

Active Compounds Identified

Researchers successfully extracted and identified four active compounds from Subabul seedpods, which marks a step in understanding the plant’s medicinal properties. The focus was on determining which compounds could effectively enhance insulin sensitivity.

Research Team and Methods

A team from the Institute of Advanced Studies in Science and Technology (IASST) conducted the study in Guwahati. They tested various extracts from the seedpods to identify the most effective bioactive fraction. This systematic approach led to the identification of the fraction that improved insulin sensitivity in muscle cells.

Key Compound – Quercetin-3-Glucoside

One of the notable compounds discovered was quercetin-3-glucoside, which plays important role in enhancing the activity of Sirtuin 1 (SIRT1). SIRT1 is an enzyme that regulates insulin sensitivity, making it vital for glucose metabolism.

Mechanism of Action

Quercetin-3-glucoside increases glucose movement across cell membranes. This action is essential for effective blood sugar control. Improved glucose uptake can lead to better management of diabetes and related health conditions.

Traditional Uses Supported

The findings support the traditional use of Subabul in treating diabetes. Many communities have relied on its leaves and immature seeds for their nutritional benefits, including protein and fibre. This research validates their historical applications in managing health issues.

The study was published in the journal ACS Omega, opens avenues for further research into natural remedies for diabetes management. The potential benefits of Subabul seedpods could lead to new therapeutic strategies.

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