IISc Scientists Discover a Method to Break Down Biofilm Barriers

 



Recent research from the Indian Institute of Science (IISc) has revealed a novel approach to combat antibiotic resistance. The study focuses on breaking down biofilm barriers that protect disease-causing bacteria. Biofilms are secreted by bacteria and act as formidable shields against drug penetration. This discovery has important implications for treating infections caused by opportunistic pathogens like Klebsiella pneumoniae.

About Biofilms

Biofilms are complex structures formed by bacteria. They consist of sugars, fats, proteins, and DNA. These layers create a protective environment for bacteria, making them resilient to antibiotics. Klebsiella pneumoniae is notorious for forming such biofilms, leading to severe hospital-acquired infections.

The Role of Enzymes

Enzymes play an important role in breaking down biofilms. The IISc team focused on polysaccharide-degrading enzymes. They aimed to disrupt the polysaccharide matrix that strengthens biofilms. The researchers identified enzymes that could effectively target and degrade these structures.

Source of Enzymes

The team explored enzymes from the bovine digestive system. Cows possess microbial enzymes that break down complex plant polysaccharides. This makes the cow’s gut an ideal source for biofilm-degrading enzymes. The researchers specifically sought glycoside hydrolases (GH), a group known for their ability to degrade polysaccharides.

Among the various enzymes, the IISc team identified GH-B2. This enzyme is found in the rumen, the largest stomach compartment of cows. It was artificially synthesised in the laboratory for further testing. The team hypothesised that GH-B2 could effectively degrade biofilms formed by K. pneumoniae.

Testing and Results

The lab-made GH-B2 was tested on four different strains of K. pneumoniae. These strains were isolated from various patients, showcasing diverse serotypes. Remarkably, GH-B2 succeeded in breaking down biofilms in all tested strains. This broad activity marks the enzyme’s potential effectiveness against varied bacterial forms.

The findings suggest a promising strategy to enhance drug delivery. By breaking down biofilm barriers, antibiotics could penetrate more effectively. This approach may reduce the incidence of antibiotic resistance in hospital settings. Enhanced treatment options could lead to better patient outcomes, especially for vulnerable populations.

Future Research Directions

Further research is needed to explore the full potential of GH-B2. Investigating its application in clinical settings could provide valuable insights. Additionally, understanding the enzyme’s mechanism of action will be crucial for optimising its use. The IISc team’s work opens new avenues for combating biofilm-associated infections.

#Antibiotics #BacterialInfections #AntibioticResistance #HealthCare #InfectionPrevention #AntibioticAwareness #Medicines #PublicHealth #MedicalScience #DrugResistance

World Cell Biologist Awards: 

Website Link : cellbiologist.org 
Nomination Link : cellbiologist.org/award-nomination/?ecategory=Awards&rcategory=Awardee Contact Us: contact@cellbiologist.org 

Follow Us On : 
Twitter : twitter.com/account/access 
Blogger : blogger.com/u/1/blog/posts/1155994660171864058 
Pinterest : pinterest.com/researchs625/?actingBusinessId=907757006050531250 
Linkedin : linkedin.com/in/research-scholar-10278a323/
Tumblr ; tumblr.com/

Comments

Post a Comment

Popular posts from this blog

Guillain-Barré Syndrome Cases in Andhra Pradesh

Image
  Recently, the state of Andhra Pradesh has witnessed a rise in Guillain-Barré Syndrome (GBS) cases, prompting government action. The Chief Minister has ordered an investigation into the outbreak. Earlier this year, Maharashtra also reported rising cases of GBS. About Guillain-Barré Syndrome Guillain-Barré Syndrome (GBS) is a rare autoimmune disorder affecting the peripheral nervous system. GBS is characterised by muscle weakness and paralysis. It typically starts with weakness, tingling, or numbness in the limbs. Symptoms can progress rapidly, leading to paralysis that may last from six months to a year. The syndrome affects nerves responsible for muscle movement and sensation. While it can occur at any age, it is more common in adult males. Causes and Triggers The exact cause of GBS remains unknown. However, it often follows infections, either bacterial or viral. The immune system mistakenly attacks the body’s nerves after such infections. Some rare cases have been linked to va...
Read more

Bharat Cancer Genome Atlas

Image
  The Indian Institute of Technology Madras recently launched the Bharat Cancer Genome Atlas (BCGA). This initiative aims to enhance cancer research in India. It addresses the under-representation of Indian genetic data in global cancer studies. The launch comes ahead of World Cancer Day and marks the increasing cancer incidence in the country. Overview of the Bharat Cancer Genome Atlas The BCGA is a comprehensive database of genetic variants linked to breast cancer in India. It collects data from breast cancer patients across the country. The goal is to identify specific biomarkers for early detection and develop targeted treatment strategies. Significance of the Initiative This initiative is crucial for understanding the unique genetic landscape of Indian cancers. The database will aid in the identification of cancer-specific biomarkers. It will also facilitate the development of diagnostic kits and targeted therapies tailored to the Indian population. Research and Collaboration...
Read more

WEF’s “Blueprint to Close the Women’s Health Gap” Report

Image
  The World Economic Forum (WEF) has released a report denoting the economic potential of addressing women’s health issues. Titled “Blueprint to Close the Women’s Health Gap,” the report reveals that improving women’s health could contribute an estimated $400 billion to global GDP by 2040. It identifies nine critical health conditions impacting women’s lives and puts stress on the need for targeted research and investment. Women’s Health Disparities Women experience 25% more years of poor health compared to men. This disparity is largely due to insufficient research and funding focused on women-specific health conditions. The report indicates that women are often overlooked in clinical trials, particularly in areas like ischemic heart disease and migraine , where only 10% include sex-specific data. Key Health Conditions Identified The report categorises nine health conditions into two groups – lifespan and health span conditions. Lifespan conditions include maternal hypertensive d...
Read more