Protein Detects and Responds to Changes in Blood Flow

 

When blood moves through your body, it exerts a frictional force on the walls of blood vessels. This force, known as fluid shear stress, has important effects on vascular development, function, and disease. A team at Yale, led by Martin Schwartz, PhD, Robert W. Berliner Professor of Medicine (cardiology), has identified a protein that helps your body sense and respond to changes in this shear stress.

This protein, latrophilin-2, is found on the surface of the cells lining the blood vessel wall. Schwartz’s team demonstrated that latrophilin-2 is activated by changes in blood flow and is required for flow-dependent blood vessel development and preclinical remodeling. Additionally, the authors found that specific variants of the gene encoding latrophilin-2 are highly associated with the development of cardiovascular disease in humans. These findings help define a novel pathway by which our blood vessels respond to changes in flow and shed new light on cell biology and genetic links to cardiovascular disease.

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